Our lab research is focused on developing cutting-edge computational tools and methods to understand physiology and disease and develop new therapies. Our research spans a wide range of physiological areas and topics, including electrophysiology, cellular and subcellular signaling pathways, and mechanobiology. We study healthy normal physiological functioning and diseases and pathologies, including cardiac arrhythmias, fibrosis, and cancer. In our lab, we use multiscale and stochastic models to study complex physiological phenomena.
Computational modeling is a multidisciplinary field, combining tools from engineering, biology, mathematics, physics, chemistry, and computational science. Over the past few decades, computational modeling has become an invaluable counterpart to experimental physiology and a powerful tool for predictive medicine – using models to understand and predict biological behavior during disease and responses to potential therapies.
5/30/2018 - Madison, Mario, Lewis, Tien, and Vrishti present at the Biology and Medicine through Mathematics conference in Richmond, Virginia.
5/24/2018 - Madison, Mario, Vrishti, and Tien present at the Virginia Academy of Science annual meeting in Farmville, Virginia.
3/1/2018 - Dr. Weinberg and Dr. Christopher Lemmon are awarded a 4-year R01 award from the National Institutes of Health!
2/19/2018 - Lewis, Tien, and Vrishti present at the Biophysical Society annual meeting in San Francisco, California.
1/11/2018 - Vrishti and Dr. Weinberg's recent paper, "Heart rate variability alters cardiac repolarization and electromechanical dynamics" was published in the Journal of Theoretical Biology. Congrats Vrishti!
12/22/2017 - Dr. Weinberg's recent paper with Dr. Christopher Lemmon, "Multiple Cryptic Binding are Necessary for Robust Fibronectin Assembly: An In Silico Study," was published in Scientific Reports.
11/21/2017 – Ana presents at the School of Engineering Undergraduate Research Symposium.
10/14/2017 – Tien and Vrishti present at the Biomedical Engineering Society (BMES) annual meeting in Phoenix, Arizona.
8/23/2017 - Dr. Weinberg's recent paper, "Ephaptic coupling rescues conduction failure in weakly coupled cardiac tissue with voltage-gated gap junctions" was published in Chaos.
8/21/2017 - Tien and Dr. Weinberg's recent paper, "Memory in a fractional-order cardiomyocyte model alters properties of alternans and spontaneous activity" was published in Chaos. Congrats Tien!
6/12/2017 – Dr. Weinberg’s recent paper, with Devin Mair and Dr. Christopher Lemmon, “Mechanotransduction Dynamics at the Cell-Matrix Interface” was highlighted by Biophysical Journal as a “New and Notable” article. Congrats!